Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548080 | 0.92 | EDNRB (0.49) | EDNRBEDNRANPC1RAB9AMEN1 | |
| SCHEMBL8551694 | 0.90 | EDNRB (0.48) | EDNRBEDNRAPLA2G2ARAB9AMEN1 | |
| SCHEMBL8552318 | 0.89 | EDNRB (0.55) | EDNRBEDNRAAGTR1AGTR2 | |
| SCHEMBL8550374 | 0.89 | EDNRB (0.43) | EDNRBEDNRAAGTR1AGTR2CA9 | |
| SCHEMBL8553553 | 0.88 | EDNRB (0.36) | EDNRBEDNRAAGTR1AGTR2PLA2G2A | |
| SCHEMBL8548304 | 0.88 | EDNRB (0.44) | EDNRBEDNRANPC1RAB9AMEN1 | |
| SCHEMBL8547617 | 0.87 | EDNRB (0.58) | EDNRBEDNRANPC1RAB9AMEN1 | |
| SCHEMBL8547683 | 0.87 | EDNRB (0.41) | EDNRBEDNRAAGTR1AGTR2PLA2G2A | |
| SCHEMBL8548108 | 0.85 | EDNRB (0.48) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8549602 | 0.84 | EDNRB (0.46) | EDNRBEDNRAPLA2G2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |