Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484959 | 0.68 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7376871 | 0.67 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL16726638 | 0.63 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABHD16A | |
| SCHEMBL7374330 | 0.63 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7380088 | 0.62 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28150069 | 0.62 | MAPT (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL14482912 | 0.62 | MEN1 (0.47) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL15330859 | 0.62 | MAPT (0.44) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL4521443 | 0.61 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL6795458 | 0.61 | KHK (0.49) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738270-B1 | DIHYDRO PYRAZOLOPYRROLES | PFIZER (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5596013-A | INHIBITORS OF PHOSPHODIESTERASE TYPE IV AND PRODUCTION OF TUMOR NECROSIS FACTOR | PFIZER INC (US) | 1997-01-21 | — | — | US | disclosed |
| US-5508300-A | INHIBIT PHOSPHODIESTERASE AND PRODUCTION OF TUMOR NECROSIS FACTOR; TREATING INFLAMMATORY DISEASES | PFIZER INC. (US) | 1996-04-16 | — | — | US | disclosed |