Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.55 |
| ▸ | EDNRA | P25101 | 12/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546724 | 0.87 | EDNRB (0.57) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL8548108 | 0.87 | EDNRB (0.48) | EDNRBEDNRA | |
| SCHEMBL8547617 | 0.85 | EDNRB (0.58) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL8551694 | 0.85 | EDNRB (0.48) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL8551727 | 0.85 | EDNRB (0.47) | EDNRBEDNRAMAPT | |
| SCHEMBL8550808 | 0.84 | EDNRB (0.67) | EDNRBEDNRA | |
| SCHEMBL8549630 | 0.82 | EDNRB (0.52) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL8547683 | 0.82 | EDNRB (0.41) | EDNRBEDNRAMEN1KMT2AMAPT | |
| SCHEMBL8553472 | 0.82 | EDNRB (0.81) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8546601 | 0.82 | EDNRB (0.51) | EDNRBEDNRAMAPTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |