Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 15/20 | 0.67 |
| ▸ | EDNRA | P25101 | 12/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550885 | 0.94 | EDNRB (0.74) | EDNRBEDNRAMEN1GAAMAPT | |
| SCHEMBL8551943 | 0.90 | EDNRB (0.68) | EDNRBEDNRAMEN1GAAMAPT | |
| SCHEMBL8547092 | 0.90 | EDNRB (0.68) | EDNRBEDNRAMAPTTP53POLB | |
| SCHEMBL8552838 | 0.89 | EDNRB (0.53) | EDNRBEDNRAMEN1GAAMAPT | |
| SCHEMBL8550951 | 0.88 | EDNRB (0.81) | EDNRBEDNRATP53POLB | |
| SCHEMBL8551619 | 0.87 | EDNRB (0.59) | EDNRBEDNRATP53 | |
| SCHEMBL8551023 | 0.87 | EDNRB (0.67) | EDNRBEDNRATP53 | |
| SCHEMBL8547526 | 0.86 | EDNRB (0.59) | EDNRBEDNRATP53POLB | |
| SCHEMBL8550228 | 0.85 | EDNRB (0.85) | EDNRBEDNRA | |
| SCHEMBL8548527 | 0.85 | EDNRB (0.73) | EDNRBEDNRAMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |