SCHEMBL855338

SCHEMBL855338

O=c1[nH]nc2c3c(cccc13)Oc1ccccc1-2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 17/20 0.59
PIM1 P11309 2/20 0.57
CSNK1D P48730 2/20 0.57
ATM Q13315 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
CDC7 O00311 1/20 0.45
PLK4 O00444 1/20 0.45
CHEK1 O14757 1/20 0.45
IKBKB O14920 1/20 0.45
RGS12 O14924 1/20 0.45
AURKA O14965 1/20 0.45
GAK O14976 1/20 0.45
NPC1 O15118 1/20 0.45
PDPK1 O15530 1/20 0.45
DAPK3 O43293 1/20 0.45
DYRK3 O43781 1/20 0.45
ROCK2 O75116 1/20 0.45
RPS6KA5 O75582 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30930832 1.00 PARP1 (0.59) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL14336647 0.85 PARP1 (0.56) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL14336470 0.84 PARP1 (0.64) PARP1PIM1CSNK1DLMNATSHR
SCHEMBL14336756 0.84 PARP1 (0.61) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL14336667 0.84 PARP1 (0.61) PARP1PIM1CSNK1DKDM4EAURKA
SCHEMBL14336617 0.81 PARP1 (0.47) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL13647432 0.81 PARP1 (0.58) PARP1PIM1CSNK1DATMNPSR1
SCHEMBL52171 0.81 PARP1 (0.70) PARP1PIM1CSNK1D
SCHEMBL13647431 0.81 PARP1 (0.61) PARP1PIM1CSNK1DGSK3AGSK3B
SCHEMBL61262 0.81 PARP1 (0.74) PARP1PIM1CSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469597-A1 COMPOSITIONS AND METHODS FOR INHIBITING STAG1 EXPRESSION AND USES THEREOF President And Fellows Of Harvard College (US) 2024-12-04 EP disclosed
EP-4376822-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES Lantern Pharma Inc. (US) 2024-06-05 EP disclosed
EP-3612234-B1 COMBINATION THERAPY WITH AN ANTI-AXL ANTIBODY-DRUG CONJUGATE ADC THERAPEUTICS SA (CH) 2024-03-13 EP disclosed
WO-2024016014-A2 METHOD FOR TREATING BREAST CANCERS AND PARP RESISTANT BREAST CANCERS LANTERN PHARMA INC. (US) 2024-01-18 WO disclosed
WO-2023147400-A1 COMPOSITIONS AND METHODS FOR INHIBITING STAG1 EXPRESSION AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-08-03 WO disclosed
WO-2023010119-A1 TREATING CANCERS WITH COMBINATIONS OF PARP INHIBITOR AND ACYLFULVENES LANTERN PHARMA INC. (US) 2023-02-02 WO disclosed
US-20220305132-A1 COMBINATION THERAPY COMPRISING AN ANTI-CD19 ANTIBODY DRUG CONJUGATE AND A PI3K INHIBITOR OR A SECONDARY AGENT OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P. 2022-09-29 US disclosed
EP-4028009-A1 TREATMENT OF HR DEFICIENT CANCER The Francis Crick Institute Limited (GB) 2022-07-20 EP disclosed
EP-3980079-A1 COMBINATION THERAPY COMPRISING AN ANTI-CD19 ANTIBODY DRUG CONJUGATE AND A PI3K INHIBITOR OR A SECONDARY AGENT ADC Therapeutics SA (CH) 2022-04-13 EP disclosed
WO-2022029223-A1 COMBINATION THERAPY COMPRISING ANTI-KAAG1 ANTIBODY DRUG CONJUGATE AND PARP INHIBITOR ADC THERAPEUTICS SA (CH) 2022-02-10 WO disclosed
EP-1684736-B1 DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER KUDOS PHARM LTD (GB) 2011-08-24 EP disclosed
WO-2011058367-A2 DIAGNOSTIC TEST FOR PREDICTING RESPONSIVENESS TO TREATMENT WITH POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR ASTRAZENECA AB (SE) 2011-05-19 WO disclosed
EP-2305221-A1 Dna damage repair inhibitors for treatment of cancer Kudos Pharmaceuticals Limited (GB) 2011-04-06 EP disclosed
US-20100249112-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS ASTRAZENECA R&D (SE) 2010-09-30 US disclosed
EP-2167086-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS AstraZeneca AB (SE) 2010-03-31 EP disclosed
WO-2008146035-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS ASTRAZENECA AB (SE) 2008-12-04 WO disclosed
US-20060142231-A1 DNA damage repair inhibitors for treatment of cancer KUDOS PHARMACEUTICALS LIMITED (GB) 2006-06-29 US disclosed
US-20050227919-A1 DNA damage repair inhibitors for the treatment of cancer KUDOS PHARMACEUTICALS LIMITED 2005-10-13 US disclosed
US-6514983-B1 Inhibitors of the nucleic enzyme poly(adenosine 5'-diphospho-ribose)polymerase GUILFORD PHARMACEUTICALS INC. 2003-02-04 US disclosed
US-6306889-B1 FUSED HETEROCYCLIC DRUGS FOR CARDIOVASCULAR DISORDERS GUILFORD PHARMACEUTICALS INC. 2001-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060142231-A1 DNA damage repair inhibitors for treatment of cancer MRE11, PARP2, ERCC4 PARP1 4/4885PIM1 3310/4885CSNK1D 3764/4885
US-20220305132-A1 COMBINATION THERAPY COMPRISING AN ANTI-CD19 ANTIBODY DRUG CONJUGATE AND A PI3K INHIBITOR OR A SECONDARY AGENT CD22, BTK, CD79B PARP1 849/4885PIM1 363/4885CSNK1D 3442/4885
US-20100249112-A1 COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS CHEK1, CHEK2, PARP1 PARP1 3/4885PIM1 499/4885CSNK1D 405/4885
US-20050227919-A1 DNA damage repair inhibitors for the treatment of cancer MRE11, ERCC4, PARP2 PARP1 7/4885PIM1 3423/4885CSNK1D 3655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.