Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.37 |
| ▸ | RET | P07949 | 5/20 | 0.37 |
| ▸ | CDK7 | P50613 | 5/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 4/20 | 0.32 |
| ▸ | FLT3 | P36888 | 4/20 | 0.32 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | PAK4 | O96013 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | FYN | P06241 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90921 | 0.81 | SMO (0.37) | NPY5RIKBKBCHUK | |
| SCHEMBL90922 | 0.79 | ALOX5AP (0.40) | NPY5R | |
| SCHEMBL90861 | 0.77 | NPY5R (0.49) | NPY5RIKBKBCHUK | |
| SCHEMBL16300948 | 0.76 | NPY5R (0.37) | NPY5RIKBKBCHUK | |
| SCHEMBL15021896 | 0.75 | ABL1 (0.43) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL90852 | 0.74 | BRD4 (0.35) | NPY5RJAK2JAK3IKBKBCHUK | |
| SCHEMBL90914 | 0.73 | NPY5R (0.34) | CDK7CDK5CLK4NPY5RFLT3 | |
| SCHEMBL90920 | 0.73 | NPY5R (0.36) | NPY5RCDK9IKBKBCHUK | |
| SCHEMBL90918 | 0.73 | NPY5R (0.36) | CDK7CDK5CLK4NPY5RFLT3 | |
| SCHEMBL91022 | 0.72 | SMO (0.37) | ABL1NPY5RIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299066-B2 | Compounds having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20120130070-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130070-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | NPY5R, NPY1R, NPY2R | ABL1 619/4885RET 637/4885CDK7 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.