Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 6/20 | 0.44 |
| ▸ | MERTK | Q12866 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9898160 | 0.93 | JAK2 (0.54) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8583535 | 0.91 | JAK2 (0.51) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8583199 | 0.91 | JAK2 (0.51) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8583537 | 0.90 | JAK2 (0.51) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8554993 | 0.89 | JAK2 (0.49) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL9947530 | 0.88 | TYRO3 (0.48) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8552237 | 0.86 | JAK2 (0.46) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8553681 | 0.86 | JAK2 (0.46) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL8596547 | 0.86 | TYRO3 (0.47) | JAK2TYRO3AXLMERTKJAK1 | |
| SCHEMBL9947526 | 0.86 | JAK2 (0.51) | JAK2TYRO3AXLMERTKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068440-A1 | HETEROCYCLIC-SUBSTITUTED PYRROLOPYRIDINES AND PYRROLOPYRIMIDINES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |