Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857920 | 0.93 | PIK3CA (0.49) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL857587 | 0.92 | PIK3CA (0.47) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL857336 | 0.88 | PIK3CA (0.48) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL3764550 | 0.88 | PIK3CA (0.46) | PIK3CAALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL859026 | 0.88 | PIK3CA (0.52) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL854559 | 0.87 | PIK3CA (0.49) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL859214 | 0.84 | PIK3CA (0.49) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL856658 | 0.84 | PIK3CA (0.49) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL855409 | 0.84 | PIK3CA (0.49) | PIK3CAFGFR1FGFR2FGFR3ALDH1A1 | |
| SCHEMBL857187 | 0.82 | PIK3CA (0.51) | PIK3CAALDH1A1USP2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |