Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | TOP2A | P11388 | 3/20 | 0.67 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501123 | 0.91 | KDM4E (0.70) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8118056 | 0.90 | KCNH2 (0.72) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8102541 | 0.90 | KCNH2 (0.72) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8111734 | 0.89 | KCNH2 (0.71) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL10531166 | 0.89 | KDM4E (0.68) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8556904 | 0.89 | KCNH2 (0.71) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| Grepafloxacin SCHEMBL29695614 | 0.88 | KCNH2 (1.00) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| Grepafloxacin SCHEMBL34157 | 0.88 | KCNH2 (1.00) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| Grepafloxacin SCHEMBL34155 | 0.88 | KCNH2 (1.00) | KCNH2HRH3KDM4EALDH1A1LMNA | |
| Grepafloxacin SCHEMBL34156 | 0.88 | KCNH2 (1.00) | KCNH2HRH3KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2815119-B2 | — | — | 1998-10-27 | — | — | JP | claimed |
| US-5563138-A | 4-OXOQUINOLINE-3-CARBOXYLIC ACID COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1996-10-08 | — | — | US | claimed |
| EP-0287951-B1 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | claimed |
| EP-0398967-A1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1990-11-28 | — | — | EP | claimed |
| EP-0326891-A2 | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-08-09 | — | — | EP | claimed |
| WO-1989006649-A2 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-07-27 | — | — | WO | claimed |
| EP-0319906-A2 | Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-06-14 | — | — | EP | claimed |
| EP-0287951-A2 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-10-26 | — | — | EP | claimed |
| US-5811576-A | 1-CARBOXY-2-LOWERALKYL-3,4,6-TRI(HALO)BENZENES; GRAMPOSITIVE AND-NEGATIVE BACTERIA; INFECTIONS; STERILIZATION OF MEDICAL EQUIPMENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-09-22 | — | — | US | disclosed |
| US-5723648-A | Intermediates for anti-microbial benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0823413-A2 | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |
| US-5585491-A | Antibacterial agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| US-5563138-A | 4-OXOQUINOLINE-3-CARBOXYLIC ACID COMPOUNDS HAVING ANTIMICROBIAL ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1996-10-08 | — | — | US | disclosed |
| EP-0287951-B1 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| EP-0364943-A2 | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-04-25 | — | — | EP | disclosed |
| US-4920120-A | 3-CARBOXY, 4-OXO, 6-FLUORO, 7-NITROGEN-CONTAINING RING 1,4-DIHYDRO-1,8-NAPHTHYRIDINES | WARNER-LAMBERT COMPANY (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0326891-A2 | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-08-09 | — | — | EP | disclosed |
| WO-1989006649-A2 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-07-27 | — | — | WO | disclosed |
| EP-0319906-A2 | Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-06-14 | — | — | EP | disclosed |
| EP-0287951-A2 | 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-10-26 | — | — | EP | disclosed |