SCHEMBL8554754

SCHEMBL8554754

ClC1=NNc2ccccc2C=C1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.48
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30082351 0.75 GAA (0.48) GAAMAPT
SCHEMBL31695999 0.75 GAA (0.48) GAAMAPT
SCHEMBL8119025 0.75 GAA (0.48) GAAMAPT
SCHEMBL9934859 0.75 GAA (0.48) GAAMAPT
SCHEMBL2386480 0.75 MAPT (0.48) GAAMAPT
SCHEMBL3113175 0.75 GAA (0.48) GAAMAPT
SCHEMBL1505206 0.75 GAA (0.48) GAAMAPT
SCHEMBL11428738 0.75 GAA (0.48) GAAMAPT
SCHEMBL3241604 0.75 MAPT (0.48) GAAMAPT
SCHEMBL6746204 0.75 GAA (0.43) GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016186559-A1 METHOD FOR INVESTIGATING BLOOD-BRAIN BARRIER PROPERTIES AND BRAIN METABOLISM USING INSECT BRAINS QUIXOLABS AB (SE) 2016-11-24 WO disclosed
CN-103221538-B Beta-glucosidase variants and polynucleotides encoding same 诺维信股份有限公司 2016-06-22 CN disclosed
CN-103635176-A Custom dyeing system COLORIGHT LTD 2014-03-12 CN disclosed
EP-0475527-B1 Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents SANOFI SA (FR) 1998-02-25 EP disclosed
US-5624922-A Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents STERLING WINTHROP INC. (US) 1997-04-29 US disclosed
EP-0597540-B1 Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents STERLING WINTHROP INC (US) 1996-06-05 EP disclosed
US-5380721-A Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents STERLING WINTHROP INC. (US) 1995-01-10 US disclosed
EP-0597540-A1 Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents STERLING WINTHROP INC. (US) 1994-05-18 EP disclosed
EP-0475527-A2 Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents STERLING DRUG INC. (US) 1992-03-18 EP disclosed
US-4246270-A TRANQUILIZERS, MUSCLE RELAXANTS, AND SEDATIVES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-01-20 US disclosed
US-4120856-A REACTING 3-HYDROXY-BENZODIAZEPINES WITH AMINOSULFUR TRIFLUORIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-10-17 US disclosed