Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.63 |
| ▸ | PRCP | P42785 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348881 | 0.90 | KDM4E (0.63) | SLC22A1PRCPBCHEKDM4EMAPT | |
| SCHEMBL9411172 | 0.90 | TBXA2R (0.67) | SLC22A1PRCPBCHE | |
| SCHEMBL10348630 | 0.89 | KDM4E (0.66) | SLC22A1PRCPBCHEKDM4EMAPT | |
| Tetrahydropapaverine SCHEMBL29375914 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL30298880 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL30441145 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL6398843 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL251076 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL1076975 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL31612469 | 0.86 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079383-A4 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION. | US SECRETARY UNITED STATES DEP (US) | 1984-01-12 | — | — | EP | claimed |
| EP-0079383-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1983-05-25 | — | — | EP | claimed |
| WO-1982004049-A1 | PREPARATION OF CHIRAL 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES BY OPTICAL RESOLUTION | US HEALTH (US) | 1982-11-25 | — | — | WO | claimed |
| EP-0617022-B1 | 6,7, dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound | BANYU PHARMA CO LTD (JP) | 1998-02-11 | — | — | EP | disclosed |
| EP-0617022-A1 | 6,7, dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-09-28 | — | — | EP | disclosed |
| EP-0154035-B1 | S-TETRAHYDROPROTOBERBERINOXIDASE, PROCESS FOR ITS PREPARATION AND ITS USE | Consortium für elektrochemische Industrie GmbH (DE) | 1990-07-25 | — | — | EP | disclosed |
| US-4657861-A | S-tetrahydroprotoberberineoxidase, process for producing the same and use thereof | CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1987-04-14 | — | — | US | disclosed |
| EP-0154035-A2 | S-tetrahydroprotoberberinoxidase, process for its preparation and its use | Consortium für elektrochemische Industrie GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |