Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225053 | 0.85 | KCNH2 (0.61) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL7246401 | 0.81 | KCNH2 (0.58) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL11904082 | 0.80 | KCNH2 (0.65) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL11928628 | 0.80 | KCNH2 (0.65) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL11904470 | 0.80 | KCNH2 (0.65) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL8554946 | 0.80 | KCNH2 (0.65) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL7219159 | 0.79 | ADORA2A (0.69) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL7207241 | 0.79 | KCNH2 (0.56) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL2791836 | 0.77 | KCNH2 (0.44) | KCNH2ADORA2AADORA1CYP3A4HTT | |
| SCHEMBL7237409 | 0.77 | KCNH2 (0.71) | KCNH2ADORA2AADORA1CYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716265-B2 | 4-quinolinemethanols as anti-malarial agents | JENRIN DISCOVERY, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-8716265-B2 | 4-quinolinemethanols as anti-malarial agents | JENRIN DISCOVERY, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2012068560-A2 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | CYP51A1, SQLE, NQO2 | KCNH2 2710/4885ADORA2A 4299/4885ADORA1 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.