SCHEMBL8556547

SCHEMBL8556547

CC(N(CC(=O)O)C(=O)c1ccc(C(F)(F)F)cc1)C(O)(Cn1cncn1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.38
KMT2A Q03164 2/20 0.36
MLYCD O95822 3/20 0.35
CYP3A4 P08684 5/20 0.35
CYP2C9 P11712 4/20 0.35
CYP2C19 P33261 4/20 0.35
CYP2B6 P20813 1/20 0.35
CYP3A5 P20815 1/20 0.35
CYP3A7 P24462 1/20 0.35
MAPK1 P28482 1/20 0.35
CYP3A43 Q9HB55 1/20 0.35
CYP46A1 Q9Y6A2 1/20 0.35
LMNA P02545 1/20 0.35
AR P10275 1/20 0.34
EGLN3 Q9H6Z9 1/20 0.34
CYP1A2 P05177 3/20 0.34
CYP2D6 P10635 3/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8556543 1.00 HSP90AA1 (0.38) HSP90AA1KMT2AMLYCDCYP3A4CYP2C9
SCHEMBL8551747 0.88 CYP3A4 (0.51) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8551744 0.88 CYP3A4 (0.51) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8553143 0.87 CYP3A4 (0.41) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL8553145 0.87 CYP3A4 (0.41) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19
SCHEMBL8829107 0.80 CYP3A4 (0.50) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8829109 0.80 CYP3A4 (0.50) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8829070 0.78 CYP3A4 (0.51) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8829071 0.78 CYP3A4 (0.51) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL8557041 0.78 CYP3A4 (0.49) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617031-B1 Orally active azole derivates URIACH & CIA SA J (ES) 1998-09-16 EP disclosed
US-5478826-A Fungicides for human, animal and plants J. URIACH & CIA. S.A. (ES) 1995-12-26 US disclosed
EP-0617031-A1 Orally active azole derivates J. URIACH & CIA. S.A. (ES) 1994-09-28 EP disclosed