Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.42 |
| ▸ | PDE4A | P27815 | 7/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551918 | 0.97 | PDE3B (0.64) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL2779004 | 0.94 | PDE3B (0.71) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL8557091 | 0.89 | PDE3B (0.63) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9638620 | 0.86 | KCNH2 (0.75) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9638626 | 0.86 | KCNH2 (0.75) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9672631 | 0.85 | PDE3B (0.59) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL8555995 | 0.85 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9672622 | 0.85 | KCNH2 (0.62) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9672618 | 0.85 | KCNH2 (0.62) | PDE3BPDE3AKCNH2PDE4BPDE4A | |
| SCHEMBL9638381 | 0.84 | KCNH2 (0.65) | PDE3BPDE3AKCNH2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721950-B1 | Cardioactive 3-alkoxycarbonyl-thiadiazinones | MERCK PATENT GMBH (DE) | 1998-05-06 | — | — | EP | disclosed |
| EP-0721950-A2 | Cardioactive 3-alkoxycarbonyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-17 | — | — | EP | disclosed |