Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31665941 | 0.88 | CYP2A6 (0.68) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL11302716 | 0.88 | CYP2A6 (0.68) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL11626337 | 0.88 | CYP2A6 (0.68) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL4288341 | 0.88 | CYP2A6 (0.68) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL27765004 | 0.88 | CYP2A6 (0.68) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL29644361 | 0.87 | CYP2A6 (0.77) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL865990 | 0.87 | CYP2A6 (0.77) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL30027002 | 0.84 | CYP2A6 (0.72) | CYP2A6TP53MAOBAHRTSHR | |
| Hydrochloric Acid SCHEMBL29200223 | 0.84 | CYP2A6 (0.72) | CYP2A6TP53MAOBAHRTSHR | |
| SCHEMBL2473615 | 0.84 | CYP2A6 (0.72) | CYP2A6TP53MAOBAHRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |