Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 5/20 | 0.65 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | OXTR | P30559 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7332888 | 0.86 | AVPR2 (0.65) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL7341183 | 0.86 | AVPR2 (0.57) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL7351134 | 0.84 | AVPR2 (0.59) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL8820844 | 0.82 | AVPR2 (0.54) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL8562104 | 0.82 | HPGD (0.58) | HPGDALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8561104 | 0.81 | AVPR2 (0.53) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL6991836 | 0.81 | AVPR2 (0.65) | AVPR2AVPR1AHPGDALDH1A1KMT2A | |
| SCHEMBL8820724 | 0.80 | AVPR2 (0.52) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL31680509 | 0.80 | HPGD (0.90) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL6965406 | 0.80 | AVPR2 (0.92) | AVPR2AVPR1AHPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| WO-1997047625-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| WO-1997047624-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |