SCHEMBL8559939

SCHEMBL8559939

CCOC(=O)CCc1ccccc1OCCCCI

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 2/20 0.56
CYP4A11 Q02928 2/20 0.56
DHFR P00374 2/20 0.49
P2RY10 O00398 8/20 0.47
GPR34 Q9UPC5 5/20 0.47
GPR174 Q9BXC1 5/20 0.46
LTB4R Q15722 1/20 0.46
LTB4R2 Q9NPC1 1/20 0.46
PPARD Q03181 1/20 0.45
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16673226 0.84 CYP4F2 (0.67) CYP4F2CYP4A11DHFRALDH1A1GAA
SCHEMBL4281161 0.82 CYP4F2 (0.56) CYP4F2CYP4A11DHFRP2RY10GPR34
SCHEMBL16972794 0.80 CYP4F2 (0.60) CYP4F2CYP4A11DHFRPPARDALDH1A1
SCHEMBL16673056 0.79 CYP4F2 (0.62) CYP4F2CYP4A11DHFRLTB4RLTB4R2
SCHEMBL7687145 0.79 CYP4F2 (0.67) CYP4F2CYP4A11ALDH1A1GAA
SCHEMBL17670843 0.78 CYP4F2 (0.66) CYP4F2CYP4A11DHFRLTB4RLTB4R2
SCHEMBL2956872 0.78 CYP4F2 (0.58) CYP4F2CYP4A11P2RY10ALDH1A1GAA
SCHEMBL13860058 0.78 CYP4F2 (0.58) CYP4F2CYP4A11ALDH1A1GAA
SCHEMBL10741672 0.78 CYP4F2 (0.65) CYP4F2CYP4A11DHFR
SCHEMBL16672611 0.78 CYP4F2 (0.69) CYP4F2CYP4A11DHFRLTB4RLTB4R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0544488-B1 Substituted phenyl phenol leukotriene antagonists LILLY CO ELI (US) 1998-03-11 EP disclosed
CN-1035001-C Substituted phenyl phenol leukotriene antagonists LILLY CO ELI (US) 1997-05-28 CN disclosed
WO-1996036347-A1 USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE ELI LILLY AND COMPANY (US) 1996-11-21 WO disclosed
EP-0743064-A1 Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease ELI LILLY AND COMPANY (US) 1996-11-20 EP disclosed
US-5462954-A Antiinflammatory, antiallergens; treating asthma ELI LILLY AND COMPANY (US) 1995-10-31 US disclosed
CN-1088906-A The phenyl phenol leukotriene antagonists that replaces LILLY CO ELI (US) 1994-07-06 CN disclosed
EP-0544488-A2 Substituted phenyl phenol leukotriene antagonists ELI LILLY AND COMPANY (US) 1993-06-02 EP disclosed