Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 13/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.31 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559552 | 0.92 | TACR1 (0.52) | TACR1 | |
| SCHEMBL8558385 | 0.88 | TACR1 (0.40) | TACR1ATM | |
| SCHEMBL8559103 | 0.87 | TACR1 (0.51) | TACR1 | |
| SCHEMBL8562658 | 0.86 | TACR1 (0.47) | TACR1 | |
| SCHEMBL8563510 | 0.82 | TACR1 (0.44) | TACR1 | |
| SCHEMBL8562925 | 0.82 | TACR1 (0.51) | TACR1 | |
| Hydrochloric Acid SCHEMBL8560263 | 0.81 | TACR1 (0.50) | TACR1 | |
| SCHEMBL8558359 | 0.81 | TACR1 (0.51) | TACR1 | |
| SCHEMBL8559375 | 0.81 | TACR1 (0.51) | TACR1 | |
| Hydrochloric Acid SCHEMBL8625895 | 0.81 | TACR1 (0.43) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |