Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856285 | 0.75 | HSD17B10 (0.53) | HSD17B10GAAKMT2AMEN1PLA2G1B | |
| SCHEMBL856413 | 0.74 | HSD17B10 (0.60) | HSD17B10KDM4EGAAKMT2AGFER | |
| SCHEMBL859649 | 0.74 | HSD17B10 (0.53) | HSD17B10KDM4EGAAKMT2AMEN1 | |
| SCHEMBL855842 | 0.73 | MEN1 (0.44) | HSD17B10KDM4EGAAKMT2AMEN1 | |
| SCHEMBL858759 | 0.73 | HSD17B10 (0.56) | HSD17B10KDM4EGAAKMT2AGFER | |
| SCHEMBL857673 | 0.73 | HSD17B10 (0.52) | HSD17B10KDM4EGAAKMT2AMEN1 | |
| SCHEMBL855801 | 0.73 | HSD17B10 (0.56) | HSD17B10KDM4EGAAKMT2AGFER | |
| SCHEMBL857674 | 0.73 | HSD17B10 (0.52) | HSD17B10KDM4EGAAKMT2AMEN1 | |
| SCHEMBL855802 | 0.73 | HSD17B10 (0.56) | HSD17B10KDM4EGAAKMT2AGFER | |
| SCHEMBL859258 | 0.73 | HSD17B10 (0.52) | HSD17B10KDM4EGAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |