Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.79 |
| ▸ | GRM5 | P41594 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350718 | 0.86 | GCK (0.72) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL21221226 | 0.86 | GCK (0.72) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL1270190 | 0.85 | NPC1 (1.00) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL3509220 | 0.85 | NPC1 (0.75) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL19820469 | 0.84 | GCK (0.69) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL19813926 | 0.84 | GCK (0.69) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL14757305 | 0.83 | GCK (0.73) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL2754003 | 0.83 | SCD (0.69) | NPC1RAB9AHPGDSMN1; SMN2LMNA | |
| SCHEMBL4757037 | 0.83 | GCK (0.58) | GCKGRM5NPC1RAB9AHPGD | |
| SCHEMBL1884815 | 0.82 | MAPT (0.73) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815108-A1 | CYCLIC UREA HIV PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-07 | — | — | EP | claimed |
| US-5683999-A | Cyclic urea HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-11-04 | — | — | US | claimed |
| EP-0815108-A1 | CYCLIC UREA HIV PROTEASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5683999-A | Cyclic urea HIV protease inhibitors | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-11-04 | — | — | US | disclosed |