Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.40 |
| ▸ | WNT3A | P56704 | 7/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9486327 | 0.87 | KCNH2 (0.34) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL11519067 | 0.84 | DYRK1A (0.44) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL8566959 | 0.80 | NOTUM (0.41) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL5198324 | 0.79 | DYRK1A (0.43) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL4734542 | 0.76 | DYRK1A (0.43) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL8139356 | 0.74 | CTNNB1 (0.51) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL7762954 | 0.73 | CTNNB1 (0.47) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL22766338 | 0.73 | PRKCI (0.49) | DYRK1ADYRK1BPRKCIDYRK2ALDH1A1 | |
| SCHEMBL22098111 | 0.72 | HTR2C (0.39) | DYRK1ADYRK1BCLK1CTNNB1WNT3A | |
| SCHEMBL6591192 | 0.71 | MAOB (0.44) | SLC6A4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115974860-A | Retinoid compound, preparation method and application thereof, and pharmaceutical composition containing compound | 复旦大学附属中山医院 | 2023-04-18 | — | — | CN | claimed |
| CN-115974860-A | Retinoid compound, preparation method and application thereof, and pharmaceutical composition containing compound | 复旦大学附属中山医院 | 2023-04-18 | — | — | CN | disclosed |
| US-5717094-A | 6-THIOCHROMANYL-ETHYNE, 6-CHROMANYL ETHYNE AND 6-TETRAHYDROQUINOLINYL ETHYNE OR THEIR METAL SALTS ARE REACTED WITH SUITABLE HALO SUBSTITUTED PHENYL OR HETEROARYL COMPUNDS | ALLERGAN (US) | 1998-02-10 | — | — | US | disclosed |
| US-5717094-A | 6-THIOCHROMANYL-ETHYNE, 6-CHROMANYL ETHYNE AND 6-TETRAHYDROQUINOLINYL ETHYNE OR THEIR METAL SALTS ARE REACTED WITH SUITABLE HALO SUBSTITUTED PHENYL OR HETEROARYL COMPUNDS | ALLERGAN (US) | 1998-02-10 | — | — | US | disclosed |
| CN-1028174-C | Process and intermediates for preparing compounds having disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN INC (US) | 1995-04-12 | — | — | CN | disclosed |
| US-5248777-A | Inhibitors of ornithine decarboxylase | ALLERGAN, INC. (US) | 1993-09-28 | — | — | US | disclosed |
| US-5248777-A | Inhibitors of ornithine decarboxylase | ALLERGAN, INC. (US) | 1993-09-28 | — | — | US | disclosed |
| US-5053523-A | Chemical intermediate for compounds having retinoic acid-like activity | ALLERGAN, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| US-5023341-A | Acetylene thiochroman | ALLERGAN, INC. (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0419132-A2 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |
| EP-0419132-A2 | Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |
| US-4980369-A | ANTIARTHRITIC AGENTS, SKIN DISORDERS, ANTIULCER AGENTS, WOUND HEALING AGENTS | ALLERGAN, INC. (US) | 1990-12-25 | — | — | US | disclosed |