Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.56 |
| ▸ | DHODH | Q02127 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.46 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328902 | 0.90 | MEN1 (0.62) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL8628278 | 0.86 | MEN1 (0.58) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL1020567 | 0.85 | MEN1 (0.67) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL7603202 | 0.83 | MEN1 (0.64) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL8563929 | 0.81 | MEN1 (0.52) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL10862774 | 0.80 | MEN1 (0.86) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL23145074 | 0.79 | MEN1 (0.74) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL31303161 | 0.79 | MEN1 (0.74) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL8560339 | 0.78 | MEN1 (0.48) | MEN1KMT2AMAPTKDM4ENPSR1 | |
| SCHEMBL8560341 | 0.78 | MEN1 (0.48) | MEN1KMT2AMAPTKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| EP-0618916-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |