Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758492 | 0.86 | PIK3CA (0.32) | PIK3CDPIK3CGPIK3CAPIK3CBNTRK1 | |
| SCHEMBL856362 | 0.85 | PIK3CA (0.34) | PIK3CDPIK3CGPIK3CAPIK3CBNTRK1 | |
| SCHEMBL3756904 | 0.84 | PIK3CA (0.34) | PIK3CDPIK3CGPIK3CAPIK3CBNTRK1 | |
| SCHEMBL15603753 | 0.83 | PIK3CA (0.32) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL856623 | 0.82 | PIK3CA (0.36) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL3758825 | 0.81 | PDE10A (0.41) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL7859193 | 0.81 | PIK3CD (0.34) | PIK3CDPIK3CGPIK3CAPIK3CBNTRK1 | |
| SCHEMBL856220 | 0.81 | PIK3CA (0.34) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL3806243 | 0.81 | PIK3CA (0.44) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL859260 | 0.81 | PIK3CA (0.35) | PIK3CDPIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |