Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.83 |
| ▸ | EGFR | P00533 | 13/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 4/20 | 0.66 |
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | KIF5B | P33176 | 2/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.61 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8904802 | 0.99 | RET (0.81) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL4371491 | 0.92 | RET (0.74) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL4383397 | 0.91 | RET (0.70) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL7976800 | 0.91 | RET (0.70) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL8976728 | 0.91 | RET (1.00) | RETEGFRCLK1ABCG2LCK | |
| Hydrochloric Acid SCHEMBL4377353 | 0.90 | RET (0.69) | RETEGFRERBB2CLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL8976571 | 0.90 | RET (0.69) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL7982775 | 0.89 | RET (0.67) | RETEGFRERBB2CLK1ABCG2 | |
| SCHEMBL4380715 | 0.89 | RET (0.70) | RETEGFRERBB2CLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL4386000 | 0.89 | RET (0.67) | RETEGFRERBB2CLK1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | claimed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | claimed |
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| US-5532261-A | TREATING STAPHYLOCOCCUS INFECTIONS | MERCK & CO., INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |