Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.34 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 2/20 | 0.31 |
| ▸ | ARG2 | P78540 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23932191 | 1.00 | PLG (0.42) | PLGPLATLMNANR1H2GABRR1 | |
| SCHEMBL23523379 | 1.00 | PLG (0.42) | PLGPLATLMNANR1H2GABRR1 | |
| SCHEMBL8510836 | 1.00 | PLG (0.42) | PLGPLATLMNANR1H2GABRR1 | |
| SCHEMBL8510838 | 1.00 | PLG (0.42) | PLGPLATLMNANR1H2GABRR1 | |
| SCHEMBL23932188 | 1.00 | PLG (0.42) | PLGPLATLMNANR1H2GABRR1 | |
| SCHEMBL8510682 | 0.84 | NR1H2 (0.37) | PLGPLATLMNANR1H2ARG1 | |
| SCHEMBL8510678 | 0.84 | NR1H2 (0.37) | PLGPLATLMNANR1H2ARG1 | |
| SCHEMBL8510680 | 0.84 | NR1H2 (0.37) | PLGPLATLMNANR1H2ARG1 | |
| SCHEMBL459196 | 0.82 | — | — | |
| SCHEMBL23933627 | 0.81 | NR1H2 (0.56) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |