Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177033 | 0.79 | TSHR (0.61) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7712867 | 0.78 | TSHR (0.58) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL10454182 | 0.77 | TSHR (0.52) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL28102250 | 0.77 | TSHR (0.52) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL27524993 | 0.76 | TSHR (0.50) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL10062449 | 0.76 | TSHR (0.50) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL3255348 | 0.75 | — | — | |
| SCHEMBL9305307 | 0.75 | CAMK2A (0.44) | TSHRLMNAKMT2A | |
| SCHEMBL17400727 | 0.74 | TSHR (0.54) | TSHRLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL12961571 | 0.74 | TSHR (0.54) | TSHRLMNAALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780633-A | Process for the preparation of indolizine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-14 | — | — | US | claimed |
| CN-1043992-C | Process for preparation of indolizine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-07-07 | — | — | CN | disclosed |
| EP-0717742-B1 | PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-11-11 | — | — | EP | disclosed |
| US-5780633-A | Process for the preparation of indolizine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-14 | — | — | US | disclosed |
| CN-1130907-A | Process for preparation of indolizine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-09-11 | — | — | CN | disclosed |
| EP-0717742-A1 | PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007279-A2 | PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-16 | — | — | WO | disclosed |