Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858681 | 0.93 | PIK3CA (0.50) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL858502 | 0.84 | CREBBP (0.50) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL13056560 | 0.84 | CREBBP (0.52) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL859137 | 0.84 | CREBBP (0.45) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL3762857 | 0.83 | PIK3CA (0.48) | CREBBPPIK3CANCF1ADRB2 | |
| SCHEMBL857156 | 0.83 | CREBBP (0.51) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL857152 | 0.82 | CREBBP (0.46) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL857161 | 0.82 | CREBBP (0.44) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL859019 | 0.82 | CREBBP (0.45) | CREBBPPIK3CAGPR142NCF1ADRB2 | |
| SCHEMBL856636 | 0.82 | CREBBP (0.44) | CREBBPPIK3CAGPR142NCF1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |