SCHEMBL8563117

SCHEMBL8563117

Nc1nc2c(c(N3CCNCC3)n1)SCCC2

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 20/20 0.42
HRH3 Q9Y5N1 8/20 0.41
KCNH2 Q12809 3/20 0.41
ADRB1 P08588 1/20 0.40
TACR2 P21452 1/20 0.40
ADRA1D P25100 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
CCR1 P32246 1/20 0.40
HRH1 P35367 1/20 0.40
AVPR1A P37288 1/20 0.40
HTR2B P41595 1/20 0.40
HTR3A P46098 1/20 0.40
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8561485 0.83 GUSB (0.43) HRH4ADRB1HTR2AHTR2CHRH1
SCHEMBL11104195 0.82 HRH1 (0.51) HRH4HTR2AHTR2CHRH1
Hydrochloric Acid SCHEMBL9383812 0.82 GUSB (0.42) HRH4ADRB1HTR2AHTR2CHRH1
SCHEMBL11106652 0.82 HRH1 (0.51) HRH4HTR2AHTR2CHRH1
SCHEMBL9381297 0.81 CHRM3 (0.35) ADRB1HTR2AHTR2CHRH1
SCHEMBL11107930 0.81 TLR9 (0.41) ADRB1HTR2AHTR2CHRH1
SCHEMBL9382612 0.81 PDE10A (0.49) HTR2AHTR2C
SCHEMBL9382754 0.80 HTR2C (0.35) HRH4HRH3KCNH2ADRB1HTR2A
SCHEMBL11101741 0.80 HTR2C (0.34) HRH4ADRB1HTR2AHTR2CHRH1
Hydrochloric Acid SCHEMBL9387840 0.80 CHRM3 (0.34) ADRB1HTR2AHTR2CHRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435566-A HYPOGLYCEMIA, ANTIHISTAMINE, ANTIDIABETIC ACTIVITY MARUKO SEIYAKU CO., LTD. (JP) 1984-03-06 US claimed
JP-59141583-A None JP disclosed
WO-1998025617-A1 SUBSTITUTED ARYL PIPERAZINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
EP-0783498-A4 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO INC (US) 1998-04-15 EP disclosed
EP-0783498-A1 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1997-07-16 EP disclosed
US-5607936-A USEFUL IN TREATMENT OF RESPIRATORY DISEASES MERCK & CO., INC. (US) 1997-03-04 US disclosed
WO-1996010568-A1 SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1996-04-11 WO disclosed
JP-S59141583-A THIOPYRANOPYRIMIDINE DERIVATIVE AND ITS ACID ADDITION SALT MARUKO SEIYAKU KK 1984-08-14 JP disclosed
US-4435566-A HYPOGLYCEMIA, ANTIHISTAMINE, ANTIDIABETIC ACTIVITY MARUKO SEIYAKU CO., LTD. (JP) 1984-03-06 US disclosed