Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL859264 | 0.94 | PIK3CA (0.38) | PIK3CACREBBPKITPDE10ASYK | |
| SCHEMBL856741 | 0.90 | PIK3CA (0.39) | PIK3CACREBBPKITPDE10ASYK | |
| SCHEMBL856324 | 0.88 | PIK3CA (0.38) | PIK3CACREBBPKITSYK | |
| SCHEMBL857832 | 0.86 | PIK3CA (0.39) | PIK3CACREBBPKITPDE10A | |
| SCHEMBL858788 | 0.86 | PIK3CA (0.41) | PIK3CACREBBPKIT | |
| SCHEMBL3758369 | 0.85 | PIK3CA (0.40) | PIK3CACREBBPKITPDE10A | |
| SCHEMBL858827 | 0.85 | PIK3CA (0.40) | PIK3CAPDE10A | |
| SCHEMBL856613 | 0.85 | PIK3CA (0.40) | PIK3CACREBBPKITPDE10A | |
| SCHEMBL859017 | 0.85 | PIK3CA (0.40) | PIK3CACREBBPKITPDE10A | |
| SCHEMBL856827 | 0.84 | PIK3CA (0.38) | PIK3CACREBBPSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |