Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP9 | P14780 | 3/20 | 0.33 |
| ▸ | MMP8 | P22894 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563390 | 1.00 | GAA (0.40) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL8563383 | 1.00 | GAA (0.40) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL29036196 | 0.80 | MAPT (0.46) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL18955109 | 0.80 | BACE1 (0.44) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL6186463 | 0.79 | MAPT (0.58) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL6419902 | 0.77 | GAA (0.43) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL30146036 | 0.77 | GAA (0.65) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL13610792 | 0.77 | GAA (0.65) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL26780527 | 0.77 | GAA (0.44) | GAAMAPTHPGDMTNR1AMTNR1B | |
| SCHEMBL26783406 | 0.77 | GAA (0.40) | GAAMAPTHPGDMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |