Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8567124 | 0.99 | PDE4B (0.62) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL9544473 | 0.87 | PDE4B (0.50) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL8563378 | 0.86 | PDE4B (0.59) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| Hydrochloric Acid SCHEMBL811230 | 0.85 | PDE4B (0.58) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL8558688 | 0.85 | PDE4B (0.60) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL8558823 | 0.84 | PDE4B (0.59) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| SCHEMBL8561277 | 0.83 | PDE4B (0.61) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| Hydrochloric Acid SCHEMBL8565121 | 0.83 | PDE4B (0.58) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| Hydrochloric Acid SCHEMBL8567867 | 0.83 | PDE4B (0.58) | PDE4BMAPTSMN1; SMN2THRBMEN1 | |
| Hydrochloric Acid SCHEMBL8563873 | 0.82 | PDE4B (0.60) | PDE4BMAPTSMN1; SMN2THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |