Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23558023 | 0.86 | ATM (0.58) | KDM4EKMT2AACLYNR1H3EGFR | |
| SCHEMBL14183990 | 0.84 | KMT2A (0.59) | KDM4EKMT2ANR1H3NR1H2EGFR | |
| SCHEMBL18585572 | 0.83 | ATF1 (0.42) | KDM4EKMT2AACLYEGFRERBB2 | |
| SCHEMBL6805255 | 0.82 | PBRM1 (0.44) | ACLYHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL493114 | 0.81 | KMT2A (0.75) | KDM4EKMT2ANR1H3NR1H2EGFR | |
| SCHEMBL9001651 | 0.81 | KMT2A (0.69) | KDM4EKMT2ANR1H3NR1H2EGFR | |
| SCHEMBL12311615 | 0.80 | KMT2A (0.64) | KDM4EKMT2ANR1H3NR1H2EGFR | |
| SCHEMBL9001629 | 0.79 | KMT2A (0.62) | KDM4EKMT2ANR1H3NR1H2EGFR | |
| SCHEMBL19933594 | 0.79 | ABL1 (0.49) | KDM4EKMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL18585849 | 0.78 | ATM (0.54) | ATMALDH1A1SMN1; SMN2MAPTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596406-B1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |