Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | NAAA | Q02083 | 5/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564012 | 1.00 | EPHX2 (0.67) | EPHX2MTNR1AMTNR1BMAPK1CA1 | |
| SCHEMBL8564020 | 1.00 | EPHX2 (0.67) | EPHX2MTNR1AMTNR1BMAPK1CA1 | |
| SCHEMBL8565940 | 0.90 | EPHX2 (0.70) | EPHX2MTNR1AMTNR1BMAPK1CA1 | |
| SCHEMBL8565942 | 0.90 | EPHX2 (0.70) | EPHX2MTNR1AMTNR1BMAPK1CA1 | |
| SCHEMBL8561735 | 0.84 | EPHX2 (0.78) | EPHX2MTNR1AMTNR1BMAPK1HDAC8 | |
| SCHEMBL8561743 | 0.84 | EPHX2 (0.78) | EPHX2MTNR1AMTNR1BMAPK1HDAC8 | |
| SCHEMBL8561739 | 0.84 | EPHX2 (0.78) | EPHX2MTNR1AMTNR1BMAPK1HDAC8 | |
| SCHEMBL8566563 | 0.81 | EPHX2 (0.62) | EPHX2MTNR1AMTNR1BMAPK1BRD4 | |
| SCHEMBL8566565 | 0.81 | EPHX2 (0.62) | EPHX2MTNR1AMTNR1BMAPK1BRD4 | |
| SCHEMBL8566568 | 0.81 | EPHX2 (0.62) | EPHX2MTNR1AMTNR1BMAPK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |