Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.56 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | MPC2 | O95563 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562482 | 0.94 | PPARG (0.56) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8565412 | 0.93 | PPARG (0.55) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8563677 | 0.93 | PPARG (0.55) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8570339 | 0.89 | FFAR1 (0.63) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8564772 | 0.88 | FFAR1 (0.62) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8564497 | 0.85 | FFAR1 (0.48) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL9570670 | 0.81 | FFAR1 (0.71) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL6931816 | 0.81 | FFAR1 (0.66) | PPARGCYP3A4RXRAFFAR1PPARA | |
| Ploglitazone SCHEMBL12160093 | 0.81 | PPARG (0.75) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8563001 | 0.81 | MAPT (0.55) | PPARGCYP3A4FFAR1PPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549366-B1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-04-15 | — | — | EP | claimed |
| US-5338855-A | Treating diabetes or hyperlipemia | SANKYO COMPANY, LIMITED (JP) | 1994-08-16 | — | — | US | claimed |
| EP-0549366-A1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-06-30 | — | — | EP | claimed |
| EP-0549366-B1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| EP-0549365-B1 | Thiazolidine compounds, their preparation and their therapeutic uses | SANKYO CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5338855-A | Treating diabetes or hyperlipemia | SANKYO COMPANY, LIMITED (JP) | 1994-08-16 | — | — | US | disclosed |
| EP-0549366-A1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-06-30 | — | — | EP | disclosed |
| EP-0549365-A1 | Thiazolidine compounds, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-06-30 | — | — | EP | disclosed |