Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15216916 | 0.82 | AVPR2 (0.66) | AVPR2AVPR1A | |
| SCHEMBL18719800 | 0.82 | MEN1 (0.63) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL7352845 | 0.81 | MAPT (0.58) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL8561766 | 0.81 | HSD17B3 (0.50) | LMNASMN1; SMN2AVPR2AVPR1A | |
| SCHEMBL8671412 | 0.81 | AVPR2 (0.67) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL7333588 | 0.80 | AVPR2 (0.47) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL27405027 | 0.79 | AVPR2 (0.61) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL5066806 | 0.77 | MAPT (0.45) | MAPTKMT2AMEN1LMNANPC1 | |
| SCHEMBL7332088 | 0.77 | AVPR2 (0.50) | MAPTKMT2AMEN1AVPR2AVPR1A | |
| SCHEMBL8268545 | 0.77 | MAPT (0.48) | MAPTKMT2AMEN1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |