Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565372 | 0.86 | PTAFR (0.41) | PTAFRITGA4ADAMTS5 | |
| SCHEMBL8561481 | 0.85 | PTAFR (0.49) | PTAFRITGA4PLAU | |
| SCHEMBL8569673 | 0.84 | PTAFR (0.38) | PTAFRITGA4PLAUADAMTS5 | |
| SCHEMBL8565374 | 0.84 | PTAFR (0.33) | PTAFRMMP1ADAM17PLAUADAMTS5 | |
| SCHEMBL8568591 | 0.82 | PTAFR (0.41) | PTAFRPLAU | |
| SCHEMBL8563029 | 0.82 | PTAFR (0.41) | PTAFRPLAU | |
| SCHEMBL8563698 | 0.78 | PTAFR (0.36) | PTAFRPLAU | |
| SCHEMBL8570622 | 0.78 | PTAFR (0.35) | PTAFRPLAU | |
| SCHEMBL8569517 | 0.78 | PTAFR (0.35) | PTAFRPLAU | |
| SCHEMBL8562738 | 0.77 | PTAFR (0.36) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | claimed |
| EP-0605434-B1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARM (GB) | 1998-08-19 | — | — | EP | disclosed |
| US-5446032-A | Platelet activsating factor antagonist | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0605434-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993002080-A1 | IMIDAZO (4,5-C) PYRIDINE DERIVATIVES AS PAF ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |