Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858310 | 0.94 | PIK3C3 (0.35) | PIK3C3PIK3CARIPK2NOD2PRKDC | |
| SCHEMBL858733 | 0.94 | PIK3C3 (0.37) | PIK3C3PIK3CARIPK2NOD2PRKDC | |
| SCHEMBL859607 | 0.94 | PIK3C3 (0.37) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL859142 | 0.94 | PIK3C3 (0.34) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL856438 | 0.93 | PIK3C3 (0.34) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL859016 | 0.93 | PIK3C3 (0.34) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL856430 | 0.93 | PIK3C3 (0.34) | PIK3C3PIK3CARIPK2NOD2PRKDC | |
| SCHEMBL856037 | 0.93 | PIK3C3 (0.35) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL858463 | 0.93 | PIK3C3 (0.34) | PIK3C3PIK3CAPRKDCENPP1KIT | |
| SCHEMBL856190 | 0.91 | PIK3C3 (0.34) | PIK3C3PIK3CAPRKDCENPP1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |