Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857217 | 0.88 | HTR2A (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL857577 | 0.81 | KDM4E (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL857578 | 0.81 | KDM4E (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL859174 | 0.78 | HTR2A (0.32) | HTR2AHTR2CHTR2B | |
| SCHEMBL858845 | 0.72 | LIMK1 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL855219 | 0.72 | LIMK1 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL855220 | 0.72 | LIMK1 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL15112226 | 0.72 | NPC1 (0.44) | — | |
| SCHEMBL15112485 | 0.72 | NPC1 (0.44) | — | |
| SCHEMBL15112353 | 0.72 | NPC1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640366-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068096-A2 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |