Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422983 | 1.00 | NPC1 (0.61) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7422992 | 1.00 | NPC1 (0.61) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7485943 | 0.86 | NPC1 (0.48) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7485949 | 0.86 | NPC1 (0.48) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7487828 | 0.86 | NPC1 (0.48) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7423800 | 0.85 | NPC1 (0.64) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7423807 | 0.85 | NPC1 (0.64) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8566008 | 0.84 | NPC1 (0.62) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8560198 | 0.84 | NPC1 (0.62) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL7424161 | 0.84 | NPC1 (0.62) | NPC1RAB9AL3MBTL1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |