Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 17/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | FBP1 | P09467 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CD38 | P28907 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569905 | 0.92 | GRM1 (0.55) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL6993332 | 0.81 | EGFR (0.59) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL7543155 | 0.78 | GRM1 (0.74) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL2998234 | 0.78 | GRM1 (1.00) | GRM1EGFRERBB2ERBB4MEN1 | |
| Hydrochloric Acid SCHEMBL7537987 | 0.77 | GRM1 (0.72) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL8568476 | 0.77 | EGFR (0.47) | EGFRERBB2MEN1KMT2A | |
| SCHEMBL238877 | 0.76 | EGFR (1.00) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL29409571 | 0.76 | EGFR (1.00) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL2993868 | 0.75 | EGFR (1.00) | GRM1EGFRERBB2ERBB4MEN1 | |
| SCHEMBL28403915 | 0.74 | EGFR (0.74) | GRM1EGFRERBB2FBP1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885226-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032881-A1 | 4-AMINO PYRIMIDINE DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |