Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GALR2 | O43603 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31352300 | 1.00 | KMT2A (0.57) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL4018126 | 0.87 | KMT2A (0.60) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL5952645 | 0.84 | KMT2A (0.59) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL9739647 | 0.83 | MAPT (0.57) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL4852458 | 0.82 | KMT2A (0.54) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL3870630 | 0.82 | MAPT (0.56) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL20718790 | 0.82 | MAPT (0.56) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7203391 | 0.82 | KMT2A (0.56) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL29511376 | 0.82 | KMT2A (0.56) | KMT2ANPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL11539572 | 0.81 | MAPT (0.61) | KMT2ANPSR1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5112824-A | Benzofurazan compounds | MERCK & CO., INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5032604-A | Class III antiarrhythmic agents | MERCK & CO., INC. (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0431944-A2 | Benzofurazan derivatives having antiarrhythmic properties | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |