Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571342 | 1.00 | KCNH2 (0.51) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8564567 | 0.92 | KCNH2 (0.44) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8569407 | 0.92 | KCNH2 (0.44) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8571203 | 0.91 | KCNH2 (0.48) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8566954 | 0.91 | KCNH2 (0.48) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10684659 | 0.88 | KCNH2 (0.53) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL9372414 | 0.88 | KCNH2 (0.53) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL10443389 | 0.88 | KCNH2 (0.53) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8566535 | 0.86 | POLB (0.68) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8566530 | 0.86 | POLB (0.68) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559752-B1 | OPTICAL ISOMERS OF 7- 3-(1,1-DIALKYLMETHYL-1-AMINO-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 1998-01-28 | — | — | EP | claimed |