SCHEMBL8567065

SCHEMBL8567065

Cc1cccc(C[C@@H](O)C=C[C@@H]2[C@@H]3[C@H](C[C@H]2O)OC(=CCCCC(=O)O)C3(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 2/20 0.41
PTGER3 P43115 2/20 0.41
PTGER1 P34995 1/20 0.41
ALDH1A1 P00352 1/20 0.41
PTGFR P43088 4/20 0.40
TBXA2R P21731 1/20 0.40
PTGER2 P43116 1/20 0.40
PPARG P37231 1/20 0.38
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8567060 1.00 PTGER4 (0.41) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL8564327 1.00 PTGER4 (0.41) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL8564323 1.00 PTGER4 (0.41) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL7019875 0.92 ABCC4 (0.38) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL7025884 0.92 ABCC4 (0.38) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL7025886 0.92 ABCC4 (0.38) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL7019873 0.92 ABCC4 (0.38) PTGER4PTGER3PTGER1ALDH1A1PTGFR
SCHEMBL7027425 0.91 PTGER4 (0.43) PTGER4PTGER3PTGER1ALDH1A1PTGER2
SCHEMBL7027428 0.91 PTGER4 (0.43) PTGER4PTGER3PTGER1ALDH1A1PTGER2
SCHEMBL7020616 0.91 PTGER4 (0.43) PTGER4PTGER3PTGER1ALDH1A1PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0669329-B1 Difluorprostacyclins, intermediates for production thereof and processes for production thereof ASAHI GLASS CO LTD (JP) 1998-05-20 EP disclosed