Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565700 | 0.92 | CHRM3 (0.56) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL6166416 | 0.91 | CHRM3 (0.52) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6168628 | 0.90 | CHRM3 (0.52) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL8570359 | 0.90 | CHRM3 (0.51) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL6169679 | 0.90 | CHRM3 (0.48) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL8571871 | 0.87 | CHRM3 (0.54) | CHRM2CHRM3OPRM1DRD2SIGMAR1 | |
| SCHEMBL8569665 | 0.83 | CCR8 (0.46) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL6165720 | 0.83 | CHRM3 (0.47) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL8571599 | 0.83 | CHRM3 (0.46) | CHRM2CHRM3OPRM1DRD2DRD4 | |
| SCHEMBL6166931 | 0.83 | CHRM3 (0.43) | CHRM2CHRM3OPRM1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |