SCHEMBL8567760

SCHEMBL8567760

O=c1[nH]c2c(F)c(F)c(F)c(F)c2c(F)c1F

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 3/20 0.62
GRIN3B O60391 3/20 0.62
GRIN1 Q05586 3/20 0.62
GRIN2A Q12879 3/20 0.62
GRIN2B Q13224 3/20 0.62
GRIN2C Q14957 3/20 0.62
GRIN3A Q8TCU5 3/20 0.62
JAK2 O60674 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2639786 0.77 GRIN2D (1.00) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL9393007 0.71 GRIN2D (0.49) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL7779406 0.65 GRIN2D (0.71) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL9389996 0.62 GRIN2D (0.41) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL24071036 0.57 GRIN2D (0.33) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL245064 0.57
SCHEMBL2252341 0.57
SCHEMBL5873399 0.54
SCHEMBL3446667 0.54
SCHEMBL979901 0.54

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840904-A Fluoro-pyridine-2,3-dicarboxylic anhydrides which are intermediates for herbicidal pyridine-2,3-dicarboximides BASF AKTIENGESELLSCHAFT (DE) 1998-11-24 US disclosed
EP-0661282-B1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AG (DE) 1998-04-22 EP disclosed
US-5679622-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1997-10-21 US disclosed
EP-0661282-A1 Pyridine-2,3-dicarboxylic imides, process for their preparation and their use to control the growth of unwanted plants BASF AKTIENGESELLSCHAFT (DE) 1995-07-05 EP disclosed