Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856549 | 0.92 | PIK3CA (0.33) | PIK3CA | |
| SCHEMBL3717364 | 0.88 | PIK3CA (0.34) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL858635 | 0.87 | PIK3CA (0.35) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL3767906 | 0.87 | KDM4E (0.34) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL7859249 | 0.85 | PIK3CA (0.33) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL15522787 | 0.84 | PIK3CA (0.35) | PIK3CA | |
| SCHEMBL3762761 | 0.84 | KDM4E (0.32) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL3768247 | 0.84 | KDM4E (0.32) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL861157 | 0.83 | PIK3CA (0.34) | PIK3CAKITKDM4ETSHRHTT | |
| SCHEMBL859124 | 0.83 | PIK3CA (0.36) | PIK3CAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432779-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | Exelixis, Inc. (US) | 2012-03-28 | — | — | EP | disclosed |