Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.78 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.78 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574162 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8605635 | 0.83 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8575060 | 0.81 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8570055 | 0.80 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8570036 | 0.78 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8574245 | 0.75 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8568390 | 0.74 | PDE4B (0.71) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7175742 | 0.73 | PDE4B (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6864050 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8691667 | 0.72 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |