Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203632 | 0.81 | MEN1 (0.44) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL7445797 | 0.76 | MEN1 (0.45) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17158260 | 0.76 | BRD4 (0.54) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL17158281 | 0.75 | BRD4 (0.44) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL10876485 | 0.75 | MEN1 (0.40) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL17158279 | 0.74 | BRD4 (0.46) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL17075024 | 0.73 | KDM4E (0.42) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL17158241 | 0.73 | BRD4 (0.42) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL17158201 | 0.73 | BRD4 (0.48) | BRD4KDM4EPOLBALDH1A1HPGD | |
| SCHEMBL32683822 | 0.71 | EPHX2 (0.39) | POLBMEN1KMT2AEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |