Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568763 | 1.00 | PTGS1 (0.42) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL8567450 | 1.00 | PTGS1 (0.42) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL28905884 | 0.85 | PTGS1 (0.42) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL764935 | 0.82 | PTGS1 (0.46) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL24473432 | 0.79 | PTGS1 (0.47) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL7784324 | 0.78 | PTGS1 (0.43) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL24015330 | 0.78 | MEN1 (0.41) | ESR1TP53 | |
| SCHEMBL547420 | 0.77 | TSHR (0.62) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL19741070 | 0.76 | ABAT (0.43) | — | |
| SCHEMBL22854082 | 0.76 | CYP2D6 (0.50) | LMNACYP2C9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643781-B1 | ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS | SEPRACOR INC (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5419817-A | Osmium tetroxide catalyst; preparing hydroxycarbonyl compounds from enol ether or vinyl halide | SEPRACOR INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0643781-A4 | ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS. | — | 1995-04-26 | — | — | EP | disclosed |
| EP-0643781-A1 | ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS | SEPRACOR, INC. (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5302257-A | Preparing optically active glycols using catalyst complex of osmium tetroxide and chiral oxidation resistant tertiary amine, employing secondary oxidant to generate osmium tetroxide, electrolytically regenerating secondary oxidant | SEPRACOR, INC. (US) | 1994-04-12 | — | — | US | disclosed |
| WO-1993017150-A1 | ELECTROCATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINIC COMPOUNDS | SEPRACOR, INC. (US) | 1993-09-02 | — | — | WO | disclosed |