Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13020232 | 0.88 | NOTUM (0.61) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL3782121 | 0.87 | NOTUM (0.62) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL3783835 | 0.87 | NOTUM (0.60) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL8803744 | 0.86 | NOTUM (0.58) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL14090157 | 0.85 | NOTUM (0.65) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL9088878 | 0.84 | NOTUM (0.66) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL29150848 | 0.84 | NOTUM (0.63) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL10716438 | 0.82 | NOTUM (0.61) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL3789114 | 0.80 | NOTUM (0.52) | NOTUMLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL8570134 | 0.80 | NOTUM (0.56) | NOTUMLMNAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| CN-1110685-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1995-10-25 | — | — | CN | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| CN-1053613-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1991-08-07 | — | — | CN | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |